3D cell culture is an in-vitro method where cells mature in artificially created surroundings, which resembles the in-vivo environment. This technique stimulates normal cell to distinguish, proliferate, and migrate by interacting with their three-dimensional environment. Normal polarization and distinction of epithelial cells are crucial for the placement of duct-like structures in in-vitro conditions, which can be achieved when the cells are cultivated in 3D cultures. Moreover, the synergistic effect required for the fundamental interaction of cell-cell and cell-extra cellular matrix (ECM), which can control the expression of molecules concerned in cell differentiation, is achieved in 3D cell cultures.
Analytical instrumental companies, private companies, pharmaceutical, and different government organizations have largely invested in the 3D cell culture projects to meet the demand of the organs development and novel drug discoveries. The heavy investments made by major companies and research organizations, growing demand for organ transplantation led to the flourishing of the market. This is proposed to be one of the important factors favoring the demand for 3D cell culture. The usage of animals in research activities and testing of health professional is ordinary since decades. However, 3D cell culture can possibly replace an animal used for research and testing. This will play a fundamental role in driving the demand for this technique during the forecast period. Definite limitations are faced by 2D cell culture technique during cellular modeling studies; 3D technique efficiently overcomes the limitations by stipulating cells with an environment that allows them to act within three dimensions. High quality of 3D over 2D cell culture method is another driver that will force the demand in the next few years. Laboratories, hospital, pharma companies, research institutes, and biotechnology entities are progressively accepting this technique for healthier results. This application is attributed to the ability of 3D cultured cells to grow more realistically compared to 2D cultured cells. One of the fashionable trends in the market today is the utilization of laboratory automation for culturing 3D cells. Small- and medium-sized pharmaceutical and laboratories players may however come across a financial challenge, as the initial investment connected with execution of 3D cell culture is costly.
Moreover, products of 3D cell culture technique mostly lack uniformity, which is another factor that may confine their demand over the forecast period. Even though, the rate of acceptance of 3D cell culture is likely to climb up during the forecast period. Increasing use of the technique in pharmaceuticals for effectively studying the effect of drug doses will also reinforce the market in the near future.
North America is hoped for dominating the market followed by Europe. The large share of this geographical segment is attributed to constituents such as growing incidence of cancer, presence of a well-established pharmaceutical and biotechnology industry, fundamental assistance from the government in the form of funds and grants, accessibility of technologically innovative products and existence of key market players. The U.S. remains at the forefront of global adoption of 3D cell cultures due to large number of research laboratories and government initiatives supporting owing to the quality R&D services in the country.
The 3D cell culture market in Republic of South Africa is proposed to grow at a CAGR of 28.4% according to WHO, during the forecast period. Increment in focus of the key players on the emerging markets such as Asia-Pacific and LAMEA contributes toward the development of the market focusing on overhauling their health care system and building the healthcare centers as the root of medical tourism. Next-generation drug development activities is gaining grip in Singapore, China, India, Malaysia, and Indonesia, which will register peak growth during forecast period due to the increasing use of 3D cell culture technology, developing health care infrastructure and rise in demand for productive medicines developed through 3D cell culture systems to treat various diseases.
Some of the major players operating in the 3D cell culture market are:
- Thermo Fisher sceintific (US)
- Lonza group (Switzerland)
- Merck and Co. (Germany)
- Synthecon, Inc. (US)
- ReproCELL Inc. (Japan)
- Mimetas Inc. (Netherlands)
- Global Cell Solutions, Inc. (US)
- 3D Biotek LLC co.(US)
- Kuraray Co. Ltd.(Japan)
- Hamilton Company (US)
- Nano3D Biosciences, Inc (US)
- QGel Co.(Switzerland).
- Corning Inc. (US)
Global 3D cell market has following segmentation
Scaffold-based 3D Cell Culture
- Hydro-gels/ECM Analogs
- Solid Scaffolds
- Micro patterned Surfaces
Scaffold-free Cell Culture
- Low-adhesion Micro plates
- Hanging Drop Plates
- 3D Bio reactors
- 3D Petri Dishes
Microfluidics-based 3D Cell Culture
Magnetic levitation & 3D Bio printing
• Cancer and Stem Cell Research
• Drug Discovery and Toxicology
• Tissue Engineering & Regenerative Medicine
By End User
- Pharmaceutical & Biotechnology Companies
- Research Institutes
Based on region
- Rest of Europe
- South Korea
- Rest of Asia pacific
- Saudi Arabia
- South Africa
- Rest of LAMEA